[生殖障碍表观遗传机制的研究进展]
Nan Jiang1, Xiaoli Zhao, Jiaqi Xu
1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300380, China. xiatian76@163.com.
概括
早期的暴露可能引发成人慢性疾病,包括生殖障碍. 母亲因素和产前环境影响卵子/胚胎发育,通过表观遗传变化影响未来的生殖健康.
科学领域:
- 生殖医学 生殖医学
- 发展生物学 发展生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 健康和疾病的发育起源 (DOHaD) 理论将早期生活因素与成人慢性疾病联系起来.
- 母亲因素和产前环境越来越被认为是对生殖健康的关键影响因素.
- 像PCOS,卵巢储备减少和子宫内膜异位症这样的生殖障碍可能源于早期发育障碍.
研究的目的:
- 审查对影响生殖障碍发病的孕产妇因素的研究.
- 阐明这些影响背后的表观遗传机制.
- 为了解成人生殖障碍的早期起源提供见解.
主要方法:
- 关于母亲因素和生殖障碍研究的文献综述.
- 对表观遗传机制的分析,包括DNA甲基化,基因素修饰和非编码RNA (miRNA) 修饰.
- 综合目前对生殖健康的DOHaD原则的理解.
主要成果:
- 母亲因素和子宫内环境可以改变早期的卵子/胚胎发育.
- 这些早期变化与多囊性卵巢综合征,卵巢储备减少和子宫内膜异位症的风险增加有关.
- 表观遗传修饰 (DNA甲基化,基因组和miRNA) 是这些效应的关键媒介.
- 代际遗传效应也可能被诱导.
结论:
- 受母亲和环境因素影响的不良早期生命暴露,显著影响成人生殖健康.
- 表观遗传机制对于将产前暴露与生殖障碍的发展联系起来至关重要.
- 了解这些早期起源对于预防和治疗成人生殖条件至关重要.
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