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环境空气污染暴露和白内障手术发生率:前性3City-Alienor研究

Laure Gayraud¹, Marion Mortamais², Cédric Schweitzer^1,3

¹Univ. Bordeaux, INSERM, BPH, U1219, Bordeaux, France.

Acta ophthalmologica

|November 11, 2024

概括

长期暴露于二氧化 (NO2) 空气污染,一个常见的环境因素,与白内障手术的风险增加有关. 遵守空气质量标准可能会减少白内障的发生率并改善公众健康.

科学领域:

环境健康环境健康
眼科医生眼科眼科
流行病学流行病学

背景情况:

白内障是全球导致失明的主要原因,与氧化压力密切相关.
了解空气污染等环境风险因素对于公共卫生战略至关重要.

研究的目的:

调查长期暴露于特定空气污染物和白内障手术发生率之间的联系.
确定空气质量,特别是二氧化 (NO2),颗粒物 (PM2.5) 和黑碳 (BC) 是否会影响白内障的发展.

主要方法:

在法国波尔多的3C-Alienor研究队列 (n=829,年龄≥65) 从1999年至2017年进行了跟踪.
使用土地利用回归模型估计了超过10年的NO2,PM2.5和BC暴露.
考克斯的比例危险模型被用来评估空气污染与白内障手术发生率之间的关联.

主要成果:

在较高的二氧化 (NO2) 度 (≥40μg/m3) 和白内障手术发生率增加 (HR=1.46,p=0.001) 之间发现了显著的关联.
在暴露于PM2.5或黑碳和白内障手术之间没有观察到统计学意义上的联系.
在14年的随访中,507名参与者接受了白内障手术.

结论:

长期暴露于高NO2水平与需要白内障手术的可能性更高有关.
遵守欧洲空气质量标准的NO2可以减轻白内障的发生率,降低医疗保健成本,提高人口的福祉.

关键词:

二氧化 (NO2) 是一种有毒的物质.空气污染空气污染白内障是什么?白内障是什么?白内障是什么?眼睛疾病眼睛疾病微细颗粒物质的细颗粒物质的细颗粒物质的细颗粒物质的细颗粒物质.氧化应激是一种氧化应激.

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