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Updated: Jun 7, 2025

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p14ARF在与NPM1相隔时形成中等尺度组件

Eric Gibbs1, Qi Miao1, Mylene Ferrolino1

  • 1Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

Nature communications
|November 11, 2024
PubMed
概括

核蛋白NPM1通过形成凝状网络来稳定瘤抑制剂p14ARF. 这种NPM1-p14ARF相互作用调节核细胞应激反应并减少细胞增殖,为癌症抑制机制提供了洞察力.

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