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一种安眠大麻成分:大麻素及其活性代谢物影响大鼠的睡眠结构
Jonathon C Arnold1,2,3, Cassandra V Occelli Hanbury-Brown4,5,6, Lyndsey L Anderson4,5,6
1Lambert Initiative for Cannabinoid Therapeutics, The University of Sydney, Sydney, NSW, Australia. jonathon.arnold@sydney.edu.au.
概括
大麻素 (CBN) 显著影响大鼠的睡眠结构,增加总睡眠时间和NREM和REM睡眠. 它的活性代谢物11-基CBN也影响睡眠,这表明它在催眠作用中发挥了作用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 睡眠科学 睡眠科学
背景情况:
- 医用大麻的使用在全球范围内不断增加,新型产品如Cannabinol (CBN) 越来越受欢迎.
- 据称CBN的营销目的是促进睡眠,但对其对睡眠架构的影响缺乏客观数据.
- 主要的大麻素,如Δ9-四大麻素 (Δ9-THC) 和大麻素 (CBD) 的特征是很好的,但小的大麻素,如CBN需要进一步的研究.
研究的目的:
- 用客观的多睡眠学研究大麻素 (CBN) 对大鼠睡眠结构的影响.
- 为了比较CBN的睡眠调节效果与传统的睡眠辅助剂.
- 确定和描述CBN的活性代谢物及其对其作用的贡献.
主要方法:
- 聚梦摄影用于记录和分析CBN给药后大鼠的睡眠模式.
- 测量了CBN及其代谢物11--CBN的脑度.
- 评估了CBN及其代谢物在CB1受体上的活性.
主要成果:
- 大麻素 (CBN) 增加了总睡眠时间,非快速眼动 (NREM) 睡眠和快速眼动 (REM) 睡眠.
- CBN对NREM睡眠的影响在规模上与常见的睡眠辅助剂佐尔皮 (zolpidem) 相当.
- 主代谢物11-基CBN达到高脑度,并表现出显著的CB1受体活性,影响睡眠结构.
- CBN对睡眠产生双相影响,最初抑制,然后增加睡眠时间.
结论:
- 大麻素 (CBN) 客观地影响大鼠的睡眠架构,支持其作为睡眠辅助剂的使用.
- 一种活性代谢物11-基CBN可能对CBN的催眠效应有显著的贡献.
- 对轻微大麻素及其代谢物进行进一步的研究是有必要的,以了解它们的治疗潜力.
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