在日本,酸性食道炎患者的真实世界治疗模式
Akinari Sawada1, Yasutaka Ihara2, Takumi Imai2
1Department of Gastroenterology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan. a.sawada@omu.ac.jp.
Scientific reports
|November 11, 2024
概括
对于性食道炎 (EoE) 的全方位维持疗法可能不需要. 质子抑制剂/竞争性酸阻塞剂的使用率迅速下降,日本EOE患者中纤维肌性并发症很少见.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 性食道炎 (EoE) 管理和普遍维持治疗的必要性仍在争论中.
- 消化管纤维化症并发症是EoE治疗中的一个问题.
- 目前的治疗指南缺乏关于长期管理策略的共识.
研究的目的:
- 为了调查在日本的性食道炎 (EoE) 治疗模式.
- 评估EOE患者食道并发症的发生情况.
- 评估在EOE管理中普遍维持治疗的需要.
主要方法:
- 基于雇主的保险索赔数据库的分析 (2005年1月 - 2022年9月).
- 包括615名被诊断患有EoE的患者.
- 卡普兰 - 梅尔方法来评估对质子抑制剂 (PPI) /竞争性酸阻断剂 (P-CAB) 治疗中止的时间.
主要成果:
- 质子抑制剂/竞争性酸阻断剂 (PPI/P-CAB) 和吞局部类固醇分别是80%和4.6%的患者的初始治疗方法.
- 在6个月内,PPI/P-CAB的使用量下降了40%,但很少再次开始使用.
- 停药PPI/P-CAB的中位时间为172天;只有1名患者出现纤维肌性并发症.
结论:
- 质子抑制剂/竞争性酸阻断剂 (PPI/P-CAB) 治疗性食道炎 (EoE) 通常是短期的.
- 食道并发症的低发病率表明,在日本的轻度EoE病例中,可能不需要通用维持疗法.
- 需要进一步的研究来优化长期的 EoE 管理策略.
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