生命早期的循环节失调会导致在成年后持久的自闭症类行为变化
Abhishek Mishra1, Hao Lin2, Rubal Singla1
1Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN, 55812, USA.
Communications biology
|November 11, 2024
概括
生命早期的昼夜干扰,模仿轮班工作,导致成年小鼠持久的自闭症类行为和认知缺陷. 这突显了昼夜节律在神经发育中的关键作用.
科学领域:
- 神经科学是一个神经科学.
- 时间生物学 时间生物学
- 发展生物学 发展生物学
背景情况:
- 循环节律调节重要的生物过程.
- 现代生活方式扰乱了昼夜节律,导致失调.
- 早期生活中昼夜干扰对神经发育和行为的长期影响尚不清楚.
研究的目的:
- 调查早期生活中昼夜干扰对成人的神经发育和行为的影响.
- 建立早期昼夜干扰与成人行为变化之间的实验联系.
主要方法:
- 使用"短日" (SD) 鼠标模型,从怀孕到产后21日的8h/8h光/黑暗周期.
- 评估成人行为,包括社交,影响,刻板印象,认知和运动功能.
- 分析了前脑区域的mTORC1/S6K1通路激活,通过西部抹杀和免疫染色.
主要成果:
- SD小鼠表现出减少的社交能力,减少的社交新奇的偏好,重复性行为和认知障碍,类似于自闭症的变化.
- SD小鼠表现出增加的焦虑和抑郁类行为以及运动功能受损.
- 在SD小鼠的前脑中观察到mTORC1/S6K1通路的过活化.
结论:
- 早期的昼夜干扰对成年人的神经化学信号和行为有持久的影响.
- 循环节律在神经发育中起着关键作用.
- 这项研究提供了实验证据,将早期的昼夜干扰与成人行为变化联系起来.
相关概念视频
01:19Autism Spectrum Disorder
67
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
67
02:19Circadian Rhythms and Gene Regulation
4.0K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.0K
01:30Attention-Deficit/Hyperactivity Disorder
44
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
44
01:28Conduct Disorder
27
Conduct disorder is a complex mental health diagnosis characterized by a repetitive and persistent pattern of behavior that violates societal norms, the rights of others, or age-appropriate rules. The diagnostic criteria for conduct disorder require the presence of at least three problematic behaviors within the past 12 months, with at least one occurring in the past six months. These behaviors are grouped into four categories: aggression toward people and animals; destruction of property;...
27
01:30Oppositional Defiant Disorder
23
A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...
Diagnostic Criteria and...
23