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在先天性腹膜的幸存者中,临床相关的神经发育障碍的风险增加:基于人口的研究
Balazs Kutasy1, Charlotte Skoglund2, Anna Löf-Granström3
1Department of Pediatric Surgery, Karolinska University Hospital, Stockholm, Sweden. balazs.kutasy@regionstockholm.se.
Pediatric surgery international
|November 11, 2024
概括
出生腹膜 (CDH) 幸存者面临神经发育障碍 (ND) 的更高风险,包括自闭症谱系障碍 (ASD) 和智力障碍. 即使没有例行查,这种风险也很明显,这突出了长期的健康问题.
科学领域:
- 儿科手术 儿科手术
- 神经发育儿科 神经发育儿科
- 公共卫生 公共卫生
背景情况:
- kongenital diaphragmatic hernia (CDH) 是一种严重的出生缺陷,已知与长期健康问题有关.
- 神经发育障碍 (ND) 是CDH后的一个常见且可能导致残疾的结果.
- 以前的评估通常依赖于查,可能缺少临床相关的NDs.
研究的目的:
- 在先天性隔膜 (CDH) 的幸存者中确定临床相关的神经发育障碍 (ND) 的发生率.
- 为了评估CDH患者的ND风险,根据症状进行评估,而不仅仅是查.
- 为了比较CDH幸存者的ND发病率与对照人群.
主要方法:
- 在瑞典进行了一项全国性的,基于人口的,前性嵌套病例控制研究.
- 这项研究包括了1982年至2015年期间在新生儿时期幸存下来的新生儿.
- 641名非综合征性CDH幸存者与3080名对照病例进行了比较.
主要成果:
- 与对照组相比,CDH幸存者出现任何ND (11.5%对5.6%),ASD (3.9%对2.1%) 和智力障碍 (6.6%对0.7%) 的发生率显著更高.
- 在CDH幸存者中,患任何ND的风险是CDH幸存者的两倍以上 (2.18倍).
- CDH幸存者患ASD (1.87倍) 和智力障碍 (10.63倍) 的风险明显更高.
结论:
- 出生腹膜的幸存者有临床相关的神经发育障碍的风险较高.
- 这种增加的风险是独立于任何查协议观察到的.
- 在CDH幸存者中早期识别和管理ND至关重要.
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