由非典型症状的Streptococcus pyogenes引起的脑:一个病例报告和文献综述
Chun-Zhen Hua1, Zhi-Peng Shen2, Ming-Ming Zhou3
1Department of Infectious Diseases, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310003, China.
BMC pediatrics
|November 11, 2024
概括
亚型链球菌 (GAS) 脑在儿童中很少见,特别是有微妙的症状. 及时诊断和治疗对于这些不常见的儿科感染的良好结果至关重要.
科学领域:
- 儿童传染病 儿童传染病
- 神经科学是一个神经科学.
- 微生物学 微生物学
背景情况:
- 杆菌 pyogenes (A组杆菌 - GAS) 是一种常见的细菌,引起各种感染.
- 由于GAS造成的脑在儿童中很少见,很少有没有急性症状的病例.
研究的目的:
- 报告一例罕见的儿科GAS脑,其临床表现异常.
- 突出早期诊断和治疗儿科GAS脑的重要性.
主要方法:
- 使用基于显微镜的神经导航系统的脑的手术切除.
- 从病变中分离和对Streptococcus pyogenes的全基因组测序.
- 患者的外周血液的全外体测序.
主要成果:
- 在该患者身上发现了IRF8基因的异构基因突变.
- 孤立的Streptococcus pyogenes (emm22基因型) 缺乏氨酸囊.
- 患者在手术排水和抗生素治疗后康复.
结论:
- 儿童Streptococcus pyogenes脑可能出现轻度或不寻常的症状.
- 早期诊断和迅速干预对于改善儿科GAS脑病例的预后至关重要.
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