在使用受惩罚的考克斯模型的肺结核患者中,与复发时间相关的因素
Zahra Mehrbakhsh1,2, Ghodratollah Roshanaei1,3, Nasser Behnampour4
1Department of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
BMC research notes
|November 11, 2024
概括
这项研究确定了影响结核病复发的关键因素,包括年龄,婚姻状况和慢性功能衰竭. 了解这些预测因素对于制定有针对性的干预措施来减少结核病复发至关重要.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 肺结核 (TB) 是一个重要的全球卫生问题,特别是在发展中国家.
- 尽管治疗方面取得了进展,但结核病复发仍然是一个挑战.
- 确定预测结核病复发的因素对于有效的公共卫生战略至关重要.
研究的目的:
- 确定影响肺结核患者复发时间的因素.
- 用先进的统计模型分析结核病复发的预测因素.
主要方法:
- 对1548名涂抹阳性肺结核患者进行了回顾性队列研究.
- 数据收集自2014年3月至2019年3月,后续调查至2021年2月.
- 使用LASSO,MCP和SCAD的分析惩罚了考克斯模型,MCP被选为最合适的模型.
主要成果:
- 考克斯模型确定了结核病复发的显著预测因素.
- 影响复发的因素包括诊断时的年龄 (>35岁),已婚和患有慢性功能衰竭.
- 治疗前涂抹结果也显示了与复发时间的关联.
结论:
- 医疗保健系统必须优先确定结核病复发预测因素.
- 根据这些因素制定有针对性的干预措施可以帮助降低复发率.
- 专注于患者的人口统计和并发性疾病可以改善结核病管理结果.
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