类风湿性关节炎和COVID-19的结果:系统性审查和元分析
Liang Jin1,2, Jianping Gan3, Xuewei Li4
1Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, China. jinghong0844@163.com.
BMC rheumatology
|November 12, 2024
概括
患有类风湿性关节炎的患者面临更高的COVID-19感染,住院,ICU入院和死亡风险. 然而,类风湿性关节炎并没有显著增加严重COVID-19疾病的风险.
科学领域:
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病.
- 了解RA患者的COVID-19风险对于公共健康至关重要.
- 需要进行系统性审查,以巩固有关RA中COVID-19结果的证据.
研究的目的:
- 进行系统的文献审查和元分析.
- 在患有类风湿性关节炎的患者中评估2019年冠状病毒病 (COVID-19) 的风险和结果.
- 为了评估COVID-19感染,严重程度,住院,ICU入院和RA患者的死亡率.
主要方法:
- 在四个电子数据库中进行系统搜索.
- 使用纽卡斯尔-太华尺度和乔安娜·布里格斯研究所检查清单进行质量评估.
- 使用STATA 14软件进行的元分析和统计分析.
主要成果:
- 在RA患者中的患病率:COVID-19 (11%),严重的COVID-19 (18%),住院 (29%),ICU入院 (10%),死亡 (8%).
- 与COVID-19感染 (OR 1.045),住院 (OR 1.319),ICU入院 (OR 1.498) 和死亡 (OR 1.377) 的风险增加相关的RA.
- 在RA和严重的COVID-19 (OR 1.354) 之间没有发现显著的关联.
结论:
- 类风湿性关节炎患者的COVID-19感染,住院,ICU入院和死亡风险明显更高.
- 类风湿性关节炎与严重COVID-19的风险增加没有显著关联.
- 针对性管理和警监测对于RA患者的COVID-19结果至关重要.
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