洞察与pH诱导的变化和头发中的蛋白质除化相关的结构和蛋白质变化
Sunil S Adav1, Alicia Rosabee Yu Ling Wu1, Kee Woei Ng1,2
1School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore.
International journal of cosmetic science
|November 12, 2024
概括
头发轴的健康取决于pH值. 极端的pH值 (酸性或性) 会损害头发结构和蛋白质. 在5到7之间的pH值是保持健康头发的理想条件.
科学领域:
- 生物化学 生物化学
- 材料科学 材料科学 材料科学
- 皮肤病学 皮肤病学
背景情况:
- 头发轴经常暴露在具有可变pH值的护发产品中.
- 头发角蛋白,作为两蛋白质,具有有限的缓冲能力,使它们容易受到pH值诱导的改变.
- 关于pH对头发质蛋白和质蛋白相关蛋白 (KAPs) 的特定影响的知识缺口.
研究的目的:
- 为了研究广泛的pH值范围 (3-12) 对头发轴结构的影响.
- 用基于质谱的蛋白质学分析不同pH值暴露后头发中的蛋白质变化.
- 为了确定保持头发健康的最佳pH值范围.
主要方法:
- 使用扫描电子显微镜检查了头发轴形态.
- 用基于质谱的蛋白质组学分析了蛋白质的变化.
- 对3-12的pH范围进行了暴露.
主要成果:
- 暴露于不同的pH值导致皮质升起和头发蛋白质组的改变.
- 观察到质素 (I和II类型) 和KAPs的显著脱化.
- 极度酸性 (pH3) 和性 (pH>8) 条件导致对头发形态和蛋白质产生明显的负面影响.
- pH 值在 5-7 之间对头发结构和蛋白质的影响最小,这表明它适用于头发健康.
结论:
- pH 在保持头发健康方面起着至关重要的作用,影响头发结构和蛋白质完整性.
- 极端的pH值 (酸性或性) 可以严重损害头发.
- 建议发护产品的pH值范围为5-7以保持头发轴的健康.
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