肠道微生物群在长寿种群中的生物合成潜力
Sheng Liu1, Zhao Zhang2, Xudong Wang1
1Shenzhen Key Laboratory of Systems Medicine for Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, China.
Gut microbes
|November 12, 2024
概括
肠道的微生物群.
科学领域:
- 微生物组研究 微生物组研究
- 自然产品的发现自然产品的发现
- 生物老龄化 生物老龄化
背景情况:
- 人的肠道微生物群对健康和衰老至关重要.
- 来自肠道微生物的天然产品具有生物活性.
- 长寿个体的肠道微生物组天然产品还没有得到充分的研究.
研究的目的:
- 在长寿人群中研究自然产品和微生物物种.
- 了解与长寿相关的生物合成基因集群 (BGCs) 的差异.
主要方法:
- 从长寿人群中整合了6个队列 (1029个便元基因组样本).
- 雇佣的元基因组单个样本组装BGC (MSSA-BGC) 分析管道.
- 组装了18个Akkermansia muciniphila基因组草案并分析了BGCs.
主要成果:
- 在极长寿和年轻人群体之间,BGC组成有很大的差异.
- 在极其长寿的群体中,基BGCs被丰富,并与Akkermansia muciniphila的丰富性有关.
- 阿克尔曼西亚 (Akkermansia muciniphila) 生产三类植物,包括霍尔斯诺C和科鲁布林酸.
结论:
- 肠道微生物组的BCCs,特别是来自Akkermansia muciniphila的基BCCs,与极端长寿有关.
- 这些微生物天然产品可能在健康调节和健康衰老中发挥作用.
- 对这些三基的进一步研究可能会揭示新的健康益处.
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