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大脑神经血管合在肌缩侧面硬化症:与疾病进展和认知障碍的相关性

Francesca Trojsi^1,2, Antonietta Canna^1,3, Minoo Sharbafshaaer¹

¹Department of Advanced Medical and Surgical Sciences, MRI Research Center, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy.

European journal of neurology

|November 12, 2024

概括

神经血管合 (NVC) 在肌缩侧硬化症 (ALS) 患者的默认模式网络 (DMN) 中减少. 这种NVC损伤可能预测疾病进展的速度更快,并有助于临床试验患者的选择.

科学领域:

神经成像是一种神经成像.
神经科学是一个神经科学.
神经学神经学

背景情况:

肌缩侧面硬化症 (ALS) 是一种进展性神经退行性疾病.
神经血管合 (NVC) 的变化,即大脑活动和血液流动之间的关系,可能表明ALS中神经血管单元功能障碍.

研究的目的:

通过在休息状态的大脑网络中关联功能连接和脑血流来研究NVC.
为了比较ALS患者和健康对照 (HCs) 之间的NVC.
根据ALS进展率来探索NVC差异.

主要方法:

从48名ALS患者和32名HC患者获得3T核磁共振扫描.
在临床上对ALS患者进行了评估,并将其分为非常快,快速或缓慢进展.
休息状态功能性MRI被用来分析大规模大脑网络中的NVC.

主要成果:

与HCs相比,在ALS患者的默认模式网络 (DMN) 中观察到NVC显著减少.
在DMN中的NVC差异在非常快进度者 (VFP) 和缓慢进度者 (SP) 之间是显著的.
在基线时受损的DMNNVC有效地区分了VFP和SP (AUC=75%) 并与认知和行为评分相关.

结论:

在DMN中减少的NVC表明ALS中广泛存在神经血管单元异常.
DMN NVC 变化可能预测更快的 ALS 进展.
对NVC的评估可能有助于在临床试验中选择和监测患者.

关键词:

骨髓缩侧面硬化症 (ALS) 是一种认知障碍是一种认知障碍.默认模式网络模式默认模式网络模式疾病的进展疾病的进展神经血管合器的神经血管合器

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