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一次剂量人类乳头瘤病毒疫苗接种:最新情况

Aimée R Kreimer¹, Deborah Watson-Jones^2,3, Jane J Kim⁴

¹Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, MD, USA.

Journal of the National Cancer Institute. Monographs

|November 12, 2024

概括

一剂人乳头瘤病毒 (HPV) 疫苗可以提供足够的保护,改善全球宫癌预防的获取和成本效益. 这种方法对于资源有限的环境至关重要.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学
公共卫生公共卫生

背景情况:

人类乳头瘤病毒 (HPV) 疫苗已经可用了二十年,在富裕国家接受率很高.
宫癌的负担在资源较少的环境中是最高的,在这些环境中,HPV疫苗的获取仍然不足.
单剂量HPV疫苗接种策略有望改善全球公平性和成本效益.

研究的目的:

更新对单剂量HPV疫苗接种疗效和耐久性的科学理解.
解决关于单剂量HPV疫苗在不同环境中的有效性知识差距.
通过疫苗接种和查,为加速宫癌控制的战略提供信息.

主要方法:

对单剂量HPV疫苗保护的初级数据的审查.
对评估疫苗有效性和耐用性的建模研究进行分析.
检查单剂量疫苗接种计划的实施策略.

主要成果:

有证据表明,单剂量HPV疫苗接种可以提供足够和持久的保护.
建模表明高成本效益和金钱的价值,特别是在低资源的设置.
世界卫生组织现在建议使用1或2剂剂的时间表,以促进更广泛的采用.

结论:

单剂量HPV疫苗接种是一种可行的策略,可以提高全球疫苗接种率,减少宫癌发病率.
将单剂量疫苗接种与一次性宫癌查相结合,可以加速疾病控制工作.
进一步的研究和实施对于最大限度地提高全球HPV疫苗接种的影响至关重要.

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