偏磁边缘病变与视网膜内层稀薄和在多发性硬化症中独立于复发活动的进展有关
Nik Krajnc1,2, Leo Hofer2,3, Fabian Föttinger1,2
1Department of Neurology, Medical University of Vienna, Vienna, Austria.
European journal of neurology
|November 12, 2024
概括
多发性硬化症 (MS) 中的偏磁边缘病变 (PRL) 与视网膜神经纤维层稀薄相关. 这种组合表明,在患有多发性硬化症的患者中,独立于复发活动 (PIRA) 的进展风险更高.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 放射学 放射学是一门学科.
背景情况:
- 偏磁边缘病变 (PRLs) 表示多发性硬化症 (MS) 的活跃炎症.
- 在患有多发性硬化症 (pwMS) 的患者中,PRL与更严重的疾病轨迹有关.
研究的目的:
- 调查视网膜层稀释与 pwMS 中的 PRL 之间的关联.
- 确定视网膜层稀释和PRL是否预测了不依赖复发活动 (PIRA) 的进展.
主要方法:
- 包括97个pwMS与大脑MRI和至少两个光学连贯性断层扫描 (OCT) 扫描.
- 使用考克斯的比例危险回归来分析周状视网膜神经纤维层 (aLpRNFL) 的年均损失,细胞内状层 (aLGCIPL) 的年均损失,PRLs和PIRA之间的关系.
主要成果:
- PRL的数量与aLpRNFL和aLGCIPL相关.
- PIRA发生在18.6%的pwMS患者中.
- aLpRNFL,aLGCIPL和PRL的数量独立地与PIRA风险增加有关.
结论:
- PRLs与内视网膜层薄化有关.
- PRLs和视网膜层一起变薄可以识别pwMS在残疾进展的高风险.
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