法里西马布在治疗抗性视网膜的耐用性和有效性,使用"现实世界"剂量方案
Shravan V Savant1, James T Kwan2, Fina Barouch1
1Department of Ophthalmology, Beth Israel Lahey Health, Burlington, Massachusetts, USA.
Journal of ophthalmology
|November 12, 2024
概括
在治疗和延长方案中切换到内法里西马布注射 (IFI) 改善了治疗间隔,并减少了治疗耐药的神经血管年龄相关黄斑变性或糖尿病黄斑胀的患者的视网膜液.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 神经血管与年龄相关的黄斑变性 (nAMD) 和糖尿病黄斑 (DME) 是导致视力丧失的主要原因.
- 对抗血管内皮生长因子 (抗VEGF) 疗法的治疗耐药性构成了临床挑战.
- 内法利西马布注射 (IFI) 提供了一个新的治疗选择.
研究的目的:
- 评估将"耐治疗"的nAMD或DME患者转换为IFI的临床结果.
- 用"现实世界"的治疗和延长 (TAE) 协议来分析疗效.
- 评估OCT治疗间隔和视网膜液的变化.
主要方法:
- 从62名先前接受抗VEGF治疗的患者71只眼睛的回顾性分析.
- 在TAE治疗方案下,患者被转换为IFI.
- 关键结果包括治疗间隔,网膜内/网膜下液体,最佳校正的视力敏度和OCT的中央子场厚度.
主要成果:
- 平均治疗间隔显著从37.6日增加到45.2天 (p=0.0016).
- 35%的眼睛在IFI后实现了无液体状态.
- 平均中心子场厚度显著下降 (p=0.0294).
- 没有观察到视力敏度或色素上皮质脱落的显著变化.
结论:
- 在TAE协议中切换到IFI可以延长"耐治疗"nAMD/DME的治疗间隔.
- 在这种患者群体中,IFI治疗在减少视网膜液体方面表现出有效性.
- 法里西马布是治疗复杂视网膜疾病的有希望的替代品.
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