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在急性,未经治疗的莱姆病期间,对完整血清特征的基于性别的分析

Alison W Rebman¹, Ting Yang¹, Jonathan M Zenilman²

¹Lyme Disease Research Center, Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Frontiers in medicine

|November 12, 2024

概括

早期莱姆病 (LD) 与淋巴缺血和高单细胞有关,男性更频繁地受到影响. 完整血清 (CBC) 分析显示,与对照组相比,LD患者的不同模式.

科学领域:

血液学血液学血液学
传染性疾病传染性疾病
流行病学流行病学

背景情况:

淋巴缺血是急性莱姆病 (LD) 的已知并发症.
全血细胞计 (CBC) 的综合分析和早期LD的基于性别的差异尚未得到充分证实.
了解LD中的CBC变异对于诊断和管理至关重要.

研究的目的:

综合分析早期LD患者的CBC值.
在早期LD患者中确定CBC参数的基于性别的趋势.
为了比较早期LD患者和对照者之间的CBC值,以及病前值.

主要方法:

分析了236名未服用抗生素的LD早期患者和61名来自美国中大西洋地区的对照组的CBC结果.
包括诊断出患有红色素移动症的患者.
中性粒细胞与淋巴细胞比率 (NLR) 的计算和性别分层分析的性能.

主要成果:

与对照组相比,早期LD患者的淋巴细胞显著降低,单细胞和NLRs较高.
淋巴细胞,单细胞和NLRs显示了从病前到急性LD的显著变化.
与女性相比,患有早期LD的男性中出现淋巴缺血的比例更高 (31.93%对19.66%).

结论:

淋巴缺血和正常的白细胞计数在LD中值得在未诊断的传染性综合征中考虑.
CBC分析,特别是淋巴缺血,可以帮助诊断LD,特别是在流行地区.
早期LD的男性患者可能更容易患有淋巴缺血症,这表明潜在的基于性别的诊断考虑.

关键词:

莱姆病是莱姆病的一种疾病.全血细胞计数的完整数目.诊断诊断诊断诊断诊断诊断血清细胞是白细胞.淋巴细胞淋巴细胞基于性别的差异.

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