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自然真和人工优化的真之间的毒性特征和比较

Lu Luo¹, Xueying Xin², Qiaochu Wang³

¹Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.

Frontiers in pharmacology

|November 12, 2024

概括

这项研究区分了天然和优化的真,发现是其药用作用的关键. 优化的真实在小鼠中表现出更高的毒性,剂量更大,表明不同的安全性.

科学领域:

矿物学是什么?矿物学是什么?
毒理学毒理学毒理学
药理学药理学是指药理学的学科.

背景情况:

具有历史医学用途的矿物质Realgar正在优化,以提高治疗潜力.
了解天然和改性真的安全性和有效性对于临床应用至关重要.

研究的目的:

评估和比较天然真和新兴人工优化的真的特性和毒性.
确保基于realgar的疗法在临床上安全使用.

主要方法:

使用物理性质和光谱特征 (ICP-MS,EPMA) 进行自然和优化的真的表征.
测量可溶含量的量.
在模拟的胃和肠液体中进行体外研究.
在KM小鼠28天内的体内毒性评估,测量肝脏和脏损伤,积和物种.

主要成果:

通过物理和光谱分析,可以区分天然和优化的真,其元素组成不同.
(As (III) 和As (V)) 被确定为体外药物作用的主要成分.
两种真实类型的肝脏和脏损伤在30毫克·公斤-1时都很小,但优化的真实在180毫克·公斤-1.1时引起的损伤明显更大.

结论:

不同的方法成功地区分了自然和优化的真实地产.
被证实是realgar药物作用的主要活性成分.
人工优化的真在高剂量下表现出比天然真更高的毒性,这需要在临床使用中考虑不同的安全性.

关键词:

的价值是.人工优化的真实gargar.毒性的毒性比较.识别特征的识别表征.自然的房地产花园

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