痴呆症患者:药物相互作用的患病率和类型
María Cristina Muñoz-Contreras1,2, Begoña Cerdá3,4, Francisco Javier López-Román5,6
1Hospital Pharmacy, Hospital La Vega, Murcia, Spain.
Frontiers in pharmacology
|November 12, 2024
概括
痴呆症患者经常经历药物相互作用 (DDI),其中87%受影响. 关键的危险因素包括多种药物和乙胆酶抑制剂,需要仔细审查治疗.
科学领域:
- 药理学 药理学是指药理学的学科.
- 老年病的医生 老年病的医生
- 临床药房 临床药房
背景情况:
- 患有阿尔茨海默氏症 (AD) 和其他痴呆症的患者容易发生多种药物治疗和与药物相关的问题.
- 伴随性疾病增加了对药物的不良影响和药物相互作用 (DDI) 的脆弱性.
研究的目的:
- 确定痴呆症患者临床相关DDI的患病率.
- 确定针对性干预的频繁相互作用和相关风险因素.
主要方法:
- 这是一项对100名痴呆症患者的观察性,描述性,横截面研究.
- 通过使用 Lexi-Interact/Lexicomp 数据库识别的潜在 DDI.
主要成果:
- 87%的患者经历了DDI,平均每患者有6.9次相互作用.
- 临床相关的DDI很常见 (共680例),严重程度往往中度 (89.8%).
- 氨酸,乙撒利酸和乙胆酶抑制剂 (AChEIs) 经常涉及;使用AChEI和多药是显著的风险因素.
结论:
- 痴呆症患者面临DDI的高风险,特别是在使用心理药物时.
- 多种药物和并发症使得临床实践中的DDI评估复杂化.
- 定期的治疗审查,考虑到药物代谢,对于在这个人群中管理DDI至关重要.
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