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Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test
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周围血液炎症指数与空腔肺结核病指数之间的关联
Xiaoshan He1, Hongbiao Hou1, Yuting Jiang1
1Department of Infectious Diseases, Meizhou People's Hospital, Meizhou Academy of Medical Sciences, Meizhou, People's Republic of China.
International journal of general medicine
|November 12, 2024
概括
炎症标志物如C反应蛋白 (CRP),血小板与淋巴细胞比率 (PLR) 和全身炎症反应指数 (SIRI) 有助于区分腔腔肺结核病 (PTB). 结合检测显示了查和排除腔性PTB的前景.
科学领域:
- 医学诊断 医学诊断 医学诊断
- 传染病 传染病 传染病
- 免疫学 免疫学 免疫学
背景情况:
- 肺结核 (PTB) 呈现于腔体和非腔体形式,需要准确的差异诊断.
- 炎症标志物越来越多地被探索,因为它们在各种疾病中的诊断效用.
研究的目的:
- 评估C反应蛋白 (CRP),中性粒细胞与淋巴细胞比率 (NLR),单细胞与淋巴细胞比率 (MLR),血小板与淋巴细胞比率 (PLR),全身免疫炎症指数 (SII) 和全身炎症反应指数 (SIRI) 的诊断性能,以区分腔内PTB与非腔内PTB.
- 确定与腔性PTB相关的独立风险因素.
主要方法:
- 对1233名PTB患者 (518名腔内,715名非腔内) 的回顾性研究.
- 炎症指数的测量方法:CRP,NLR,MLR,PLR,SII,SIRI. 这些指数可用于:
- 采用了接收器操作特征 (ROC) 曲线分析和物流回归分析.
主要成果:
- 所有评估的炎症标志物 (CRP,NLR,MLR,PLR,SII,SIRI) 在腔内PTB患者中明显高于非腔内PTB患者 (p<0.001).
- 确定了每个指数的最佳诊断值和AUC值.
- 后勤回归确定性别,CRP,PLR和SIRI作为空洞性PTB的独立风险因素.
- 对CRP,PLR和SIRI的联合检测显示出比单个标记物更高的灵敏度.
结论:
- 升高的CRP,PLR和SIRI水平与空洞性PTB的可能性增加有关.
- CRP,PLR和SIRI的组合显示出作为查工具的潜力,用于识别腔内PTB,并可能有助于排除这种形式的疾病.
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