基于广泛的巴西实验室数据库的禁食胰岛素和HOMA-IR参考间隔的建议
Yolanda Schrank1,2, Rosita Fontes1,3, Andrea Faria Dutra Fragoso Perozo1
1Diagnósticos da América S.A. São PauloSP Brasil Diagnósticos da América S.A. (DASA), São Paulo, SP, Brasil.
Archives of endocrinology and metabolism
|November 12, 2024
概括
这项研究确定了里约热内卢成年人禁食胰岛素和HOMA-IR的参考间隔. 研究结果表明,胰岛素抵抗标志物的一般参考间隔适用于两性.
科学领域:
- 内分泌学 在内分泌学.
- 临床化学 临床化学
- 公共卫生 公共卫生
背景情况:
- 胰岛素抵抗 (IR) 是代谢健康的一个关键因素.
- 准确的IR诊断依赖于可靠的标记物,如禁食胰岛素和胰岛素抵抗 (HOMA-IR) 指数的恒温模式评估.
- 建立可靠的参考间隔 (RIs) 对于准确的IR诊断至关重要.
研究的目的:
- 在里约热内卢居住的成年人中确定禁食胰岛素和HOMA-IR的参考间隔 (RIs).
- 为了研究这些胰岛素抵抗标志物在性别之间的RI潜在差异.
主要方法:
- 来自里约热内卢大型实验室数据库的血清胰岛素水平的追溯分析.
- 在应用排除标准后,纳入了21,684名个人 (年龄在20-60岁).
- 使用R包的计算挖矿方法估计RI.
主要成果:
- 已确定的95%的快速胰岛素RIs为2.54-13.30μU/mL (女性),2.43-11.89μU/mL (男性) 和2.52-13.14μU/mL (整体).
- 对于HOMA-IR的95%确定的RI:0.39-2.86 (女性),0.38-2.81 (男性) 和0.39-2.86 (整体).
- 尽管胰岛素水平和HOMA-IR的性别差异在统计上显著,但性别特定的RI被认为是不必要的.
结论:
- 为整个人口确定的禁食胰岛素和HOMA-IR的参考间隔适用于里约热内卢的两性.
- 禁食胰岛素的推RI为2.52-13.14μU/mL (15.1-78.8 pmol/L),而HOMA-IR的推RI为0.39-2.86.
- 这些发现支持在这个人群中使用统一的参考间隔来评估胰岛素抵抗.
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