血清直接胆红素作为乳腺癌的生物标志物
Jinxi Hu1, Yangjun Cai1, Yijun Chen2
1Department of Oncological Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, People's Republic of China.
Breast cancer (Dove Medical Press)
|November 12, 2024
概括
血清直接胆红素 (DB) 是乳腺癌的一个重要风险因素. 升高的DB水平表明更高的风险,并显示为乳腺癌检测的诊断标记物的潜力.
科学领域:
- 生物化学 生物化学
- 在瘤学瘤学.
- 医学诊断 医学诊断 医学诊断
背景情况:
- 血清总胆红素 (TB) 和其亚型,如血清直接胆红素 (DB),在癌症中的作用仍然存在争议.
- 之前的研究尚未确定血清DB与乳腺癌风险之间的关联或其诊断实用性.
研究的目的:
- 为了研究血清直接胆红素 (DB) 水平与乳腺癌之间的关联.
- 评估血清DB在乳腺癌检测中的诊断效用.
主要方法:
- 一项涉及5299名新诊断乳腺癌患者和10028名健康对照者的队列研究.
- 后勤回归分析以确定血清DB与乳腺癌之间的关系.
- 接收器操作特征 (ROC) 曲线分析,以评估血清DB的诊断准确性.
主要成果:
- 与健康对照人群相比,乳腺癌患者的血清DB度显著更高 (P < 0.001).
- 血清DB被确定为乳腺癌的一个独立风险因素 (OR=4.504,95% CI:4.200-4.831).
- 诊断乳腺癌的最佳切断值为2.75μmol/L,AUC为0.712,具有良好的特异性 (77.0%) 和NPV (77.8%).
结论:
- 血清直接胆红素 (DB) 是乳腺癌的确诊危险因素.
- 血清DB证明了乳腺癌的有前途的诊断潜力.
- 血清DB可以作为乳腺癌查和诊断的有价值的血清分子标记物.
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