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紫外线激光诱导的周期性表面结构对合金的骨质生成活性产生积极影响

Luiz Schweitzer^1,2, Janosch Schoon², Niklas Bläß²

¹Fraunhofer Institute for Production Systems and Design Technology, Berlin, Germany.

Frontiers in bioengineering and biotechnology

|November 12, 2024

概括

在Ti6Al7Nb植入物上激光诱导周期性表面结构 (LIPSS) 增强骨细胞功能,减少细菌生物膜的形成. 这种表面修改显示了改善关节塑性术的长期结果的希望.

科学领域:

生物材料科学生物材料科学
整形外科工程整形外科工程
表面工程是什么?表面工程是什么?

背景情况:

骨科植入物失败可能是由于松动或感染造成的.
表面地形影响骨质整合和细菌粘附.
激光诱导周期性表面结构 (LIPSS) 提供了一种修改植入物表面的方法.

研究的目的:

研究UV-LIPSS对人类骨质母细胞 (hOB) 和黄金葡萄球菌生物膜形成的影响.
评估LIPSS对细胞外基质形成和微生物附着的影响.
评估UV-LIPSS作为骨科植入物材料的表面修饰.

主要方法:

在Ti6Al4V和Ti6Al7Nb合金磁盘上产生UV-LIPSS.
使用扫描电子显微镜分析了表面地形.
评估了hOBs的细胞活力,增殖,骨质功能和细胞因子释放.
黄金葡萄球菌生物膜的形成量化.

主要成果:

紫外线LIPSS创造了周期结构 (223 nm ≤ λ ≤ 278 nm).
在LIPSS处理表面的hOB中,性酸酶活性上调.
在UV-LIPSS Ti6Al7Nb上观察到减少的促炎细胞因子释放和减少的黄金葡萄球菌生物膜形成.
金属离子释放在合金之间有所不同,但细胞金属水平没有受到影响.

结论:

Ti6Al7Nb的UV-LIPSS纹理对HOB骨质功能和细胞因子分泌有积极的影响.
在UV-LIPSS Ti6Al7Nb表面上观察到生物膜形成的减少.
这些发现表明,对长期关节整形术的结果有潜在的益处.

关键词:

关节质复原关节质复原关节质复原关节质复原生物膜是一种生物膜.细胞因子释放细胞因子释放人类骨质母细胞.激光诱导的周期性表面结构.表面地形图表表面地形图表

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