TransmiR v3.0:一个更新的转录因子-微RNA调节数据库
Maodi Liang1, Chenhao Zhang2, Yang Yang3
1School of Sports Medicine, Wuhan Institute of Physical Education, No.461 Luoyu Rd. Wuchang District, WuHan 430079 Hubei Province, China.
Nucleic acids research
|November 12, 2024
概括
更新的TransmiR v3.0数据库提供了广泛的转录因子 (TF) -微RNA (miRNA) 调节数据. 本资源有助于通过提供精心策划和预测的监管网络来了解疾病中的miRNA放松管制.
科学领域:
- 分子生物学分子生物学
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
背景情况:
- 微RNAs (miRNAs) 调节基因表达,并与病理状况有关.
- 了解miRNA转录调节对于疾病机制研究至关重要.
- 现有的数据库可能缺乏全面的TF-miRNA相互作用数据.
研究的目的:
- 提供一个更新和扩展的TransmiR v3.0数据库.
- 提供关于转录因子 (TF) -miRNA调节关系的全面信息.
- 增强数据库的实用性,用于研究miRNA生物发生和疾病.
主要方法:
- 从科学文献 (2285篇论文) 中整理了TF-miRNA规则.
- 整合来自ChIP-seq数据 (>600万对) 的TF-miRNA规则.
- 使用在miRNA促进子序列上的图案扫描来预测TF-miRNA规则.
主要成果:
- TransmiR v3.0包含5095个精选和>600万个ChIP-seq衍生的TF-miRNA规则.
- 该数据库涵盖29个生物体的3260个TF,4253个miRNA和514,433个TF-miRNA对.
- 产生了284,527个预测的TF-miRNA规则;增加了增强的注释和网络功能.
结论:
- TransmiR v3.0是一个显著扩展TF-miRNA转录调节的资源.
- 该数据库有助于对miRNA生物发生,疾病放松管制和性别特异性影响的研究.
- 增强的在线平台提供了更好的数据可访问性和分析工具.
更多相关视频
10:48Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
Published on: April 12, 2015
10.0K
07:19Identifying Targets of Human microRNAs with the LightSwitch Luciferase Assay System using 3'UTR-reporter Constructs and a microRNA Mimic in Adherent Cells
Published on: September 28, 2011
36.1K
相关概念视频
01:22MicroRNAs
3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
02:23Master Transcription Regulators
6.9K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
6.9K