怀孕相关结直肠癌后的发病率,以及孕妇和新生儿结局:基于人口的链接数据研究
Sultana Farhana1, Jane Frawley1, Nadom Safi2
1School of Public Health, Faculty of Health, University of Technology Sydney, Ultimo, New South Wales, Australia.
The journal of obstetrics and gynaecology research
|November 12, 2024
概括
澳大利亚新南威尔士州的怀孕相关结直肠癌 (PACRC) 发病率正在上升. 孕期癌症的妇女面临严重的并发症,她们的婴儿有更高的早产和不良结果的风险.
科学领域:
- 产科和妇科 产科和妇科
- 在瘤学瘤学.
- 围产儿医学 围产儿医学
背景情况:
- 怀孕期间结肠直肠癌 (CRC) 是罕见的,但具有重大风险.
- 了解怀孕相关结直肠癌 (PACRC) 的发生率和结果对于母亲和婴儿的健康至关重要.
- 之前的研究对PACRC趋势和围产期结果的数据有限.
研究的目的:
- 为了确定澳大利亚新南威尔士州 (NSW) 的PACRC发病率.
- 分析受PACRC影响的母亲和婴儿的围产期结局.
- 为了识别随着时间的推移PACRC发病率的趋势.
主要方法:
- 基于人口的队列研究,使用链接的新南威尔士州数据.
- 包括在怀孕期间被诊断患有结直肠癌的妇女 (妊娠期CRC) 或产后 (产后CRC).
- 与一组没有癌症分娩的妇女进行了比较.
主要成果:
- 在1,786,078例出生中,发现了123例PACRC病例 (22例妊娠,101例产后).
- PACRC发生率为6.9/100,000个出生,每年显著增加5.8% (1994-2013).
- 妊娠期CRC与更高的严重孕产妇并发症 (AOR 29.27) 和干预措施 (AOR 4.39) 相关;婴儿早产的几率更高 (AOR 9.91) 和新生儿不良后果 (AOR 8.65).
结论:
- 新南威尔士州的PACRC发病率显著增加,无论母亲的年龄如何.
- 妊娠期CRC出生需要增加干预,因为增加了母亲和新生儿的发病率.
- 进一步的研究和改进的查策略可能需要用于早期检测.
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