海绵中的古细胞:复杂命运的简单细胞
Alexander Ereskovsky1,2, Nikolai P Melnikov3, Andrey Lavrov3
1Aix Marseille University, Institut Méditerranéen de Biodiversité et d'Ecologie (IMBE), CNRS, IRD, Avignon University, chemin de la Batterie des lions, Station marine d'Endoume, Marseille, 13007, France.
Biological reviews of the Cambridge Philosophical Society
|November 12, 2024
概括
海绵中的古细胞不是一种普遍的干细胞类型. 这项研究重新定义了考古细胞作为特异性的Demospongiae,提出提出.
科学领域:
- 细胞生物学 细胞生物学
- 动物学 动物学
- 进化生物学 进化生物学
背景情况:
- 考古细胞在历史上被认为是海绵 (Porifera) 中的多功能细胞,特别是成年干细胞 (ASC).
- 一个多世纪以来",古细胞"一词一直被含糊地使用,导致关于其真实性质和功能的持续辩论.
- 早期的研究,主要是关于demosponges,建立了古细胞的概念ASCs,影响了几十年的海绵生物学研究.
研究的目的:
- 综合修订考古细胞的概念,检查它们的历史背景,分类学分布,特征和功能.
- 为了澄清不同海绵类别内的古细胞的特定作用和身份.
- 根据当前的证据,为具有古细胞形态的细胞提出更精确的术语.
主要方法:
- 关于海绵古细胞的历史和当代数据的全面审查和修订.
- 在不同的海绵类 (Porifera) 中对不同细胞类型进行比较分析.
- 评估现有的组织学,形态学和新出现的分子数据.
主要成果:
- 考古细胞被提出为特定于类的细胞类型,在其他海绵类中没有明确的同类.
- 在菌体中,古细胞是松散定义的中基细胞,缺乏特定的区分特征,表明潜在的异质群体.
- 在成年基因菌中干细胞功能的证据是有限的;古细胞可能与二元干细胞系统中的细胞合作.
- 在体中具有古细胞形态的细胞在消化和免疫中充当巨细胞,并被提议称为"核性氨基细胞".
结论:
- 考古细胞作为普遍的海绵干细胞的传统,广泛的概念需要修订.
- 考古细胞应该被认为是Demospongiae的特异性,它们在成年组织中的干细胞作用需要进一步证实.
- 建议使用一个更中立的术语,即"核氨基氨基细胞",用于具有古细胞形态的巨类细胞.
- 术语"古细胞"应该保留给那些被证明或被认为是干细胞的细胞.
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