阴离子第一排过渡金属糖酸复合物与三二二甲基) 胺:合成,结构和抗癌研究
Ceyda Icsel1, Seyma Aydinlik2, Muhittin Aygun3
1Department of Chemistry, Faculty of Science, Karadeniz Technical University, 61080 Trabzon, Turkey. cydyilmaz@ktu.edu.tr.
Dalton transactions (Cambridge, England : 2003)
|November 12, 2024
概括
含有 (Mn) 和铁 (Fe) 的新型过渡金属复合物对癌细胞具有强烈的细胞毒性活性. 铁复合物通过活性氧物种和DNA损伤诱导细胞死亡,这表明潜在的抗癌应用.
科学领域:
- 无机化学 无机化学 有机化学
- 药用化学 医学化学
- 材料科学 材料科学 材料科学
背景情况:
- 开发用于治疗应用的新型金属复合物.
- 探索第一排过渡金属用于抗癌药物发现.
- 糖酸盐 (sac) 和三二二甲基胺 (tpma) 金属复合物的合成和表征.
研究的目的:
- 合成和表征新的阴离子第一排过渡金属复合物.
- 评估这些复合体对各种癌症细胞系的体外细胞毒性活性.
- 研究最强效复合物的作用机制.
主要方法:
- 复杂的合成和结构特征 (元素分析,UV-Vis,IR,ESI-MS,NMR,X射线衍射,导电性).
- 针对A549,MCF7,HT29和BEAS-2B细胞系的体外细胞毒性测定.
- 细胞成像分析,ROS检测,线粒体功能障碍评估,以及对Fe.complex的DNA损伤评估.
主要成果:
- 成功合成和表征了六种过渡金属复合物:Mn,Fe,Co,Ni,Cu和Zn.
- 在所有测试的癌症细胞系中,Mn和Fe复合体表现出强烈的细胞毒性 (IC50值为1.996.67μM).
- Fe复合物诱导了细胞内显著的ROS积累,线粒体功能障碍和DNA双链断裂,通过内在途径导致细胞亡.
结论:
- 和铁复合体显示出显著的抗癌潜力.
- 铁复合物的机制涉及ROS生成,线粒体损伤和DNA断裂,最终导致亡.
- 对这些金属复合物的进一步研究可能会导致新的癌症治疗方法.
相关概念视频
Stereoisomerism
11.8K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
11.8K
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions
1.8K
Arenediazonium substitution reactions occur when the diazonium group is substituted by various functional groups such as halides, hydroxyl, nitrile, etc. For instance, arenediazonium salts react with copper(I) salts of chloride, bromide, or cyanide to form corresponding aryl chlorides, bromides, and nitriles. These reactions are named Sandmeyer reactions. Although the mechanism of this reaction is complicated, as illustrated in Figure 1, they are believed to progress via an aryl copper...
1.8K
Structural Isomerism
19.1K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
19.1K
Diazonium Group Substitution: –OH and –H
2.7K
Nitrous acid, a weak acid, is prepared in situ via the reaction of sodium nitrite with a strong acid under cold conditions. This nitrous acid prepared in situ reacts with primary arylamines to form arenediazonium salts. Such reactions are known as diazotization reactions. As shown in Figure 1, the formation of arenediazonium salts begins with the decomposition of nitrous acid in an acidic solution to give nitrosonium ions.
2.7K
Complexation Equilibria: The Chelate Effect
463
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
463
1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism
3.7K
Nitrous acid is a relatively weak and unstable acid prepared in situ by the reaction of sodium nitrite and cold, dilute hydrochloric acid. In an acidic solution, the nitrous acid undergoes protonation when it loses water to form a nitrosonium ion—an electrophile. Nitrous acid reacts with primary amines to give diazonium salts. The reaction is called diazotization of primary amines.
3.7K


