糖尿病前期与临床结果的风险增加有关,即使没有进展到糖尿病
Mary R Rooney1,2, Amelia S Wallace3,4, Justin B Echouffo Tcheugui4,5
1Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. mroone12@jhu.edu.
糖尿病前期显著增加了诸如心力衰竭和脏疾病等并发症的风险,即使糖尿病没有发展. 这种高风险的大部分仍然存在,即使考虑到糖尿病的进展.
科学领域:
- 内分泌学 在内分泌学.
- 心血管疾病流行病学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 前糖尿病与微血管和宏血管并发症的风险增加有关.
- 考虑到糖尿病的进展后,这些风险的持续程度尚不清楚.
研究的目的:
- 研究糖尿病前期和主要临床结果发生率之间的关联.
- 确定这些风险中可归因于糖尿病进展的比例.
主要方法:
- 对来自社区动脉样硬化风险研究 (ARIC) 的10,310名参与者的分析.
- 考克斯回归用于评估糖尿病前期和~30年并发症发生率 (ASCVD,心力衰竭,CKD,死亡率) 之间的关联.
- 时间变化的变量方法来解释介入的糖尿病发病率.
主要成果:
- 前糖尿病与任何并发症的风险略微增加有关 (HR 1.21).
- 在考虑到糖尿病进展后 (HR 1.18),这种关联仍然显著.
- 85%的糖尿病前期并发症风险过高,即使考虑到糖尿病的进展,仍然存在.
结论:
- 糖尿病的进展占与糖尿病前期相关的临床结果风险的不到四分之一.
- 糖尿病前期独立地对临床结果的风险作出贡献,无论糖尿病的进展如何.
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