酸可以改善因暴露于环境颗粒物而引起的泌尿器官功能障碍
Khojasteh Hoseinynejad1, Mohammad Mehdi Abdi2, Akram Ahangarpour1
1Department of Physiology, Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Naunyn-Schmiedeberg's archives of pharmacology
|November 12, 2024
概括
由颗粒物 (PM) 造成的环境污染会通过氧化应激引起功能障碍和泌尿器官损伤. 酸 (CGA) 通过增强抗氧化剂防御,显示出保护这种损伤的潜力.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 生殖生物学 生殖生物学
背景情况:
- 氧化应激是与环境污染有关的疾病中已知的机制.
- 将空气污染与泌尿器官功能障碍联系在一起的证据有限.
- 暴露于颗粒物 (PM) 对公众健康的担忧越来越大.
研究的目的:
- 调查PM影响泌尿器官功能的机制.
- 评估酸 (CGA) 对大鼠PM诱导的泌尿器官损伤的保护作用.
- 探索氧化应激和OXR1信号通路的作用.
主要方法:
- 维斯塔鼠被暴露在PM (PM10) 中4周.
- 这些组接受了不同剂量的CGA (100, 200, 400 mg/kg) 或是对照组.
- 评估脏生物标志物,氧化应激标志物,抗氧化酶,基因表达 (OXR1, Nrf2, P21),精子数,激素和组织组织学.
主要成果:
- 暴露于PM引起功能障碍和精子数量减少,与氧化应激增加有关 (MDA更高,TAC更低,SOD,CAT,GSH).
- 暴露于颗粒物下调了OXR1,Nrf2和P21基因表达.
- 通过促进抗氧化酶和调节OXR1通路,CGA治疗改善了泌尿器官生物标志物和组织结构.
结论:
- 环境空气污染,特别是PM,有助于功能障碍和泌尿器官损伤.
- 通过OXR1,P21和Nrf2路径调节氧化应激是一种关键机制.
- 基酸显示出作为一种保护性或治疗性剂对PM诱导的泌尿器官损伤的承诺.
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