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在中度至重度活跃的克罗恩病或性结肠炎患者对肠急症和缓解的患者感知:一种定性研究
Theresa Hunter Gibble1, Larissa Stassek2, Gale Harding2
1Eli Lilly and Company, 893 S Delaware St., Indianapolis, IN, 46225, USA. hunter_theresa_marie@lilly.com.
肠急症对性结肠炎 (UC) 和克罗恩病 (CD) 的患者产生重大影响. 缓解,以减少急性和改善日常功能来定义,即使有一些残留急性症状,也可以实现.
科学领域:
- 胃肠病学 胃肠病学
- 患者报告的结果
- 炎症性肠病 (IBD) 研究研究
背景情况:
- 肠急性是性结肠炎 (UC) 和克罗恩病 (CD) 的常见且具有影响力的症状.
- 肠急症对CD和患者定义的缓解标准的具体影响仍未得到充分研究.
- 了解患者的观点对于管理IBD症状至关重要.
研究的目的:
- 探索患者对中度至重度UC和CD的肠急症的看法.
- 为了确定肠急性缓解的患者定义的标准.
- 评估肠急症对IBD患者日常生活的影响.
主要方法:
- 使用半结构面试进行的定性研究.
- 使用概念诱导和认知面试.
- 紧急情况数值评级表 (UNRS) 用于评估紧急情况的严重程度和缓解值.
主要成果:
- 四十名成年人 (19 UC, 21 CD) 参与,报告了对身体,社会,职业和情感福祉的重大影响.
- 许多人经历了与紧急情况相关的便失禁.
- 患者将缓解定义为正常的肠道运动和减少急迫性,使日常活动无惧.
结论:
- 肠急性是UC和CD患者的一个关键问题,缓解显著改善生活质量.
- 患者可以在UNRS分数为4或5的缓解中考虑肠急性,这表明需要量身定制的治疗目标.
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