在口腔状细胞癌中延迟局部复发的流行病学和组织病理学因素
Hyosik Kim1, Sang-Min Lee1, Kang-Min Ahn2
1Department of Oral and Maxillofacial Surgery, College of Medicine, Asan Medical Center, University of Ulsan, Seoul, South Korea.
Maxillofacial plastic and reconstructive surgery
|November 12, 2024
概括
口腔状细胞癌 (OSCC) 的局部延迟复发 (DLR) 不常见. 组织学差异化显著影响复发间隔,建议对更高度瘤进行更密切的随访.
科学领域:
- 在瘤学瘤学.
- 口腔病理学 口腔病理学
- 手术瘤学手术瘤学
背景情况:
- 口腔状细胞癌 (OSCC) 经常在治疗后两年内复发.
- 延迟局部复发 (DLR),发生两年后,在OSCC管理中是一个不太常见但重要的事件.
- 了解DLR对于完善后续策略和改善患者治疗结果至关重要.
研究的目的:
- 调查与口腔状细胞癌 (OSCC) 延迟局部复发 (DLR) 相关的组织病理特征.
- 确定DLR的潜在预测因子,以优化患者监测协议.
主要方法:
- 从197名接受初级手术的OSCC患者的流行病学和组织病理学数据分析.
- 包括诸如瘤部位,TNM分期,等级,入侵深度,淋巴结转移和治疗方式 (RT,ND) 等特征.
- 统计分析以确定组织病理特征与DLR间隔之间的关联.
主要成果:
- 在51例局部复发中,10例 (20.83%) 被归类为DLR.
- DLR病例显示原发性瘤部位和阶段不同;80%没有淋巴结转移.
- 在DLR病例中,分化良好的瘤占主导地位 (90%),70%的侵袭深度>5毫米.
- 组织学差异化与复发间隔显著相关 (p=0.031).
结论:
- 在OSCC中延迟局部复发 (DLR) 很少发生,但会发生.
- 组织学差异化是与瘤复发时间相关的关键因素.
- 具有较高组织学等级的患者在手术后的最初两年内需要更密集的随访.
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