基于炎症和营养指数的动态变化,针对III-IV鼻癌患者的预后诺基图
Guangyi Cheng1,2, Shiwang Yuan3, Jiang Wang1,2
1The First School of Clinical Medicine, Xuzhou Medical University, 9 Kunpeng Road, Xuzhou, Jiangsu, People's Republic of China.
概括
动态炎症和营养标志物预测鼻癌 (NPC) 患者的无进展生存率. 一个新的预后模型超越了TNM对III-IVA NPC阶段的分期,改善了生存预测.
科学领域:
- 在瘤学瘤学.
- 医学统计 医学统计
背景情况:
- 鼻癌 (NPC) 是一种重要的癌症.
- 第三阶段-IVA NPC需要有效的预后工具.
研究的目的:
- 评估NPC治疗后炎症和营养指数的动态变化.
- 开发和验证无进展生存 (PFS) 的预后模型.
主要方法:
- 对279名III期-IVA NPC患者的回顾性分析.
- 使用COX回归,拉索和博鲁塔方法进行变量选择和模型构建.
- 使用bootstrap,C-index,校准图和卡普兰-梅尔曲线验证了模型.
主要成果:
- 临床阶段,三角淋巴细胞,三角单细胞,三角蛋白,三角血小板与淋巴细胞的比率,以及三角系统性免疫炎症指数与PFS显著相关.
- 开发的预后模型实现了0.712的C指数,超过了TNM分期系统 (C指数=0.597).
结论:
- 动态的炎症和营养指数有效预测NPC的预后.
- 已建立的预后模型准确地预测了III-IVA NPC患者的1年和3年的PFS.
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