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与杜皮卢马布相关的双边结膜乳头瘤和角膜穿孔
Nicholas Dewhurst1, Conor Larney2, Dale Jobson2,3
1Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
Cornea
|November 12, 2024
概括
对亚托皮性皮炎的杜皮卢马布治疗可能会导致严重的眼睛问题,包括结膜乳头瘤和角膜穿孔. 这一案例凸显了使用这种药物的患者需要眼科监测的必要性.
科学领域:
- 眼科医生 眼科 眼科
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
背景情况:
- 亚托皮炎是一种慢性炎症性皮肤疾病.
- 杜皮卢马布是一种用于治疗中度至重度亚托皮性皮炎的生物药物.
- 眼部副作用是杜皮卢马布治疗的一个已知的问题.
研究的目的:
- 报告人类乳头瘤病毒相关的结膜乳头瘤和导致穿孔的严重角膜的独特病例,该病例发生在用dupilumab治疗的患者身上.
- 审查与dupilumab相关的严重角膜副作用的文献.
主要方法:
- 一个27岁的男性患者的病例报告,患有阿托皮性皮炎,接受了dupilumab的治疗.
- 对与杜皮卢马布相关的眼部并发症的文献综述.
- 角膜和结膜乳头瘤的临床检查,诊断和治疗.
主要成果:
- 患者在开始服用dupilumab后出现结膜炎,结膜乳头瘤和眼睛干燥.
- 在14个月内,由于中枢角膜和扩散结膜乳头瘤,他经历了快速的视力损失.
- 尽管接受了治疗,但角膜进展为穿孔,需要进行角膜移植.
结论:
- 这是与杜皮卢马布相关的第三例角膜穿孔病例,也是首例与结膜乳头瘤相关的病例.
- 对这些潜在的严重眼部并发症的提高认识对于医疗保健提供者处方dupilumab至关重要.
- 在dupilumab治疗期间出现眼部症状的患者可能需要进行眼科监测.
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