保持比率损伤螺旋计 (PRISm) 与所有原因死亡率的关联:一个纵向队列研究
Yunjoo Im1, Taeyun Kim2, Jung Hye Hwang3
1Division of Pulmonology, Allergy, and Critical Care Medicine, Department of Internal Medicine, Kyung Hee University Hospital, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Annals of the American Thoracic Society
|November 12, 2024
概括
维护比例减弱螺旋计 (PRISm) 增加了死亡风险,特别是当强迫生命能力 (FVC) 较低时. 这一发现凸显了FVC严重程度在评估PRISM相关死亡风险方面的重要性.
科学领域:
- 肺部医学 肺部医学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 保留比率受损螺旋计 (PRISm) 与不良结果有关.
- PRISM严重程度,特别是强迫生命能力 (FVC) 降低对死亡率的具体影响尚未明确.
研究的目的:
- 调查PRISm与全因死亡率之间的关联.
- 在PRISm中确定具有显著增加死亡风险的子组.
主要方法:
- 追溯分析了超过10万名40岁以上的接受健康查的人 (2003-2020年).
- 预测FEV1/FVC≥0.7和FEV1<80%的PRISM定义. 预测FEV1/FVC≥0.7和FEV1<80%的预测. 预测FEV1/FVC≥0.7和FEV1<80%的预测. 预测FEV1<80%的预测.
- 将其分类为正常的肺功能,PRISM具有正常的FVC,PRISM具有低的FVC组.
主要成果:
- 与正常肺功能相比,PRISm与43%更高的死亡率有关 (aHR, 1.43).
- 低FVC的PRISM显示出明显更高的死亡风险 (aHR,1.47),而不是正常FVC的PRISM (aHR,1.25).
- 在10年的时间里,106,458名参与者中有2,219人死亡.
结论:
- PRISm是增加全因死亡率的重要风险因素.
- 降低强迫生命能力 (FVC) 加剧了PRISm患者的死亡风险.
- FVC损伤的严重程度是PRISM预后的一个关键因素.
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