三糖糖体质指数与美国成年人的抑郁症之间的关联:一个横截面研究
Lu Zhang1, Haiyang Sun2, Jiahui Yin3
1The First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Public health
|November 12, 2024
概括
三糖糖-体质指数 (TyG-BMI) 显示了与抑郁症的U形联系. 较高的TyG-BMI与抑郁症的增加有关,但在拐点以下,它可能会降低抑郁症的风险.
科学领域:
- 代谢健康和精神健康.
- 慢性疾病标志物的流行病学.
背景情况:
- 胰岛素抵抗与抑郁症有关.
- 三糖糖-体质指数 (TyG-BMI) 是胰岛素耐药性的标志物.
- TyG-BMI与抑郁症之间的关系需要进一步研究.
研究的目的:
- 调查TyG-BMI与抑郁症患病率之间的关联.
- 使用来自国家健康和营养检查调查 (NHANES) 的数据.
主要方法:
- 来自NHANES (2011-2020) 的9673名美国成年人 (≥20岁) 的横截面研究.
- 通过患者健康问卷 (9项) 评估抑郁症状.
- 进行了多变量逻辑回归,子组和值和效应分析,并对许多共同变量进行了调整.
主要成果:
- 在TyG-BMI和抑郁症患病率之间观察到U形关系.
- 在TyG-BMI的转折点被确定在174.4.4.
- 在174.4以下,增加的TyG-BMI与抑郁症患病率的降低相关;在174.4以上,与患病率的增加相关.
结论:
- TyG-BMI与抑郁症呈现出复杂的U形关联.
- 较高的TyG-BMI水平与抑郁症患病率的增加有显著联系.
- 这种关系是微妙的,在低于拐点的TyG-BMI水平下,可能会产生保护作用.
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