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SARS-CoV-2主要蛋白酶 (M-pro) 突变概况:对突变冷点的洞察力

Pol Garcia-Segura1, Ariadna Llop-Peiró1, Nil Novau-Ferré1

  • 1Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Research group in Cheminformatics & Nutrition, Campus de Sescelades, 43007, Tarragona, Spain.

Computers in biology and medicine
|November 12, 2024
PubMed
概括

研究人员在SARS-CoV-2主要蛋白酶 (M-pro) 中确定了32个关键突变冷点. 这些保存的残留物对M-pro结构至关重要,并且可能是开发新抗病毒药物的目标,用于抗击COVID-19和未来的冠状病毒爆发.

关键词:
在3CL-Pro中使用3CL-Pro.在 COVID-19 疫情中,阻碍了二聚化抑制的作用.基因组特征分析 基因组特征分析这就是M-Pro的M-Pro.突变的冷点是突变的冷点.

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