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针对治疗耐药抑郁症的单边和双边测量突发刺激:自然主义观察研究的后续研究

Mariam Elnazali¹, Ashan Veerakumar², Mervin Blair³

¹Lawson Health Research Institute, London, ON, Canada.

Journal of psychiatric research

|November 12, 2024

概括

甲爆刺激 (TBS) 是有效的治疗耐药性抑郁症 (TRD). 与单边TBS相比,双边TBS可能会提供更快的反应时间和更好的焦虑减轻.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
医疗技术医疗技术医学技术

背景情况:

甲突发刺激 (TBS) 是一种新兴的治疗耐药性抑郁症 (TRD) 的跨磁刺激技术.
有限的比较数据存在于单边与双边TBS在自然的临床环境中.
这项研究评估了TBS在更大的TRD队列中的有效性和可持续性.

研究的目的:

在更大的TRD队列中复制双边TBS的有效性.
为了比较单边和双边TBS之间的治疗结果.
确定TBS结果的基线预测因素,并评估长期响应的可持续性.

主要方法:

161名TRD患者接受单边或双边TBS的回顾性图表审查.
数据收集包括反应,缓解率,治疗持续时间和焦虑症状得分 (GAD-7).
长达6个月的随访数据评估了治疗的可持续性.

主要成果:

双边TBS的响应率为47%,单边TBS为36%;缓解率分别为34%和26%,没有显著差异.
双边TBS平均需要更少的治疗 (27对29),并且治疗后的焦虑症状显著减少.
没有基线因素预测了治疗结果;69%的响应者在没有进一步干预的情况下在6个月内保持了他们的状态.

结论:

对于TRD,TBS是有效的,并且耐受性很好.
双边TBS可能在抗焦虑作用和潜在的更快的反应时间方面提供优势.
长期响应的可持续性是有希望的,支持TBS作为一个可行的TRD治疗选择.

关键词:

双边连续的达爆发刺激 (bsTBS)左间歇的达爆发刺激 (liTBS)自然主义者研究自然主义的研究.结构方程建模 (SEM) 结构方程建模泰达爆发刺激 (TBS) 的方法治疗耐药性抑郁症的治疗方法

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