多克索鲁比辛,帕克利塔克塞尔和西斯普拉丁 (ATP) 治疗复发性/逆转性生殖细胞瘤
Jenny J Xiang1, Matthew T Campbell1, Shi-Ming Tu2
1The University of Texas MD Anderson Cancer Center, Houston, TX.
Clinical genitourinary cancer
|November 12, 2024
概括
多克索鲁比,帕克利塔塞尔和西斯 (ATP) 化疗为复发/耐药生殖细胞瘤 (GCT) 患者提供了一种可行的救援选择. 这种疗法显示出有希望的结果和耐受性,作为进一步治疗的潜在桥梁.
科学领域:
- 医学瘤学 医学瘤学
- 癌症治疗方法 癌症治疗方法
- 临床研究 临床研究
背景情况:
- 复发性/耐药性生殖细胞瘤 (GCT) 的治疗途径有限,预后不佳.
- 有效的救援化疗方案对于改善高级GCT的结果至关重要.
研究的目的:
- 评估门诊性多克索鲁比辛,帕克利塔克塞尔和西斯普拉丁 (ATP) 治疗方案的疗效和安全性,用于复发性/耐药性GCT患者.
- 评估ATP作为一个救援治疗和一个潜在的桥梁到其他疗法.
主要方法:
- 在2017-2022年期间,对35名复发性/耐药性GCT患者进行ATP治疗的回顾性分析.
- 根据治疗目标,患者被分为非息性和息性意图队列.
主要成果:
- 非息性意图队列 (24名患者) 实现了37.5%的客观应答率 (ORR),中位数无进展生存 (PFS) 为4.3个月,中位数整体生存 (OS) 为13.1个月.
- 缓解性意图队列 (11名患者) 的ORR较低,为9%,PFS中位数为0.92个月,平均生存期为5.2个月.
- 治疗毒性是可控的,有14%需要降低剂量,14%需要住院治疗,主要是因为骨髓抑制.
结论:
- ATP疗法是一种可行的,耐受性良好的化疗选择,适用于曾经未服用过 antracycline 的患有复发性/耐药性 GCT 的患者.
- 继续使用西斯在患者之前基于西斯的治疗方案是安全的,支持ATP在救援设置中的作用.
- ATP可以作为后续治疗的有效桥梁,如干细胞移植,手术或放射治疗.
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