长期暴露于聚钢微塑料会通过铁化诱导纤维化
Runyang Hong1, Yujie Shi2, Zhencheng Fan2
1Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, China; Department of Orthopedics, Affiliated Hospital of Yangzhou University, Yangzhou, China.
Toxicology
|November 12, 2024
概括
微塑料 (MP) 通过炎症和纤维化引起损伤. 一项新的研究揭示了MPs在细胞中诱导铁亡,这种过程在特定的抑制剂下是可逆的,为MP毒性提供了洞察力.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 微塑料 (MP) 污染正在增加,引发了人们对人类健康的担忧.
- 脏被确定为MP积累和毒性的主要目标器官.
- 慢性MP暴露造成脏毒性的机制尚未完全理解.
研究的目的:
- 为了研究聚乙烯 (PS) 和氨基功能化聚乙烯 (PS-NH2) 微塑料的毒性.
- 阐明长期暴露于MP的损伤背后的机制.
- 探索MP诱导的损伤的潜在治疗干预措施.
主要方法:
- 动物模型 (老鼠) 在饮用水中暴露于MPs六个月.
- 在体外研究中,使用暴露于MPs的管状皮细胞.
- 分析炎症标志物,纤维化指标和铁亡途径.
主要成果:
- 慢性MP暴露通过炎症和炎症细胞积累诱导纤维化.
- 长期的MP暴露在体外通过ferritinophagy触发了管状上皮细胞中的ferroptosis.
- 暴露于MP导致TGF-β1分泌和随后的纤维细胞激活.
结论:
- 微塑料通过炎症和铁灭菌诱导纤维化.
- 费里丁和TGF-β1信号传递是MP诱导脏毒性的关键途径.
- 抑制铁亡可以防止MP诱导的纤维化和纤维细胞激活.
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