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Updated: Jul 19, 2026

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详细的初级局部皮肤结节性amyloidosis的临床和病理工作报告

Mahaa Ayub1,2, Lizabeth Kaminoff3, Alisha Maity4

  • 1Thomas Jefferson University Sidney Kimmel Medical College, Philadelphia, Pennsylvania, USA mxa612@students.jefferson.edu.

BMJ case reports
|November 12, 2024
PubMed
概括

主要局部皮肤结节性粉症是一种罕见的皮肤疾病,没有系统性参与. 这一案例突出了近40年的陈述,强调了皮肤活检诊断的必要性.

关键词:
皮肤病学 皮肤病学血液学 (包括输血)病理学 病理学 病理学

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...