通过单粒子ICP质谱测量进行微/纳米尺寸化的基于强度和时间的策略:使用Au和SiO2作为模型粒子进行比较评估
Antonio Bazo1, Eduardo Bolea-Fernandez1, Ana Rua-Ibarz1
1University of Zaragoza, Department of Analytical Chemistry, Aragon Institute of Engineering Research (I3A), Zaragoza, 50009, Spain.
Analytica chimica acta
|November 12, 2024
概括
单粒子ICP质谱法 (SP-ICP-MS) 提供了先进的微/纳米粒子 (MNP) 大小测量. 独立于TE的方法和基于时间的方法显示出有希望的结果,而独立于TE的方法在MNP的表征中产生了最低的不确定性.
科学领域:
- 分析化学 分析化学
- 材料科学 材料科学 材料科学
背景情况:
- 单粒子ICP质谱法 (SP-ICP-MS) 是微/纳米粒子 (MNP) 大小测量的关键技术.
- 传统的SP-ICP-MS方法通常依赖于综合强度和运输效率 (TE) 计算.
- 进步使得TE独立和基于时间的尺寸方法成为可能.
研究的目的:
- 系统地评估和比较不同的SP-ICP-MS方法论用于MNP大小.
- 确定每个方法的优点和弱点.
- 为特定应用选择合适的SP-ICP-MS技术提供指导.
主要方法:
- 评估 TE-依赖的方法 (粒子频率,粒子大小) 和 TE-独立的方法 (外部校准,相对方法).
- 利用传输时间信号的基于时间的方法的评估.
- 使用的金纳米粒子 (AuNPs) 和二氧化微/纳米粒子 (SiO2MNPs) 用于验证.
主要成果:
- 与TE依赖方法相比,TE独立方法显示的不确定性最低.
- 颗粒大小方法的准确性取决于参考MNP选择.
- 基于时间的方法对AuNP有效,但对较大的SiO2MNP效果较差.
结论:
- 独立于TE的方法和过境时间监控是未充分利用的SP-ICP-MS策略.
- 对方法的定量比较对于推进MNP大小测定至关重要.
- 开发工具,比如用于传输时间测量的Python脚本,有助于应用新技术.
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