临床实践的最新进展:掌握挑战 - 管理IBD中的IBS症状
Judith Wellens1,2, João Sabino1,2, Tim Vanuytsel1,2
1Gastroenterology and Hepatology, KU Leuven University Hospitals Leuven Gasthuisberg Campus Hospital Pharmacy, Leuven, Belgium.
Gut
|November 12, 2024
概括
患有炎症性肠病 (IBD) 的患者在炎症消失后也经常出现类似于刺激性肠综合征 (IBS) 的症状. 这篇评论强调了共享的病理生理学,并强调了聚焦肠-大脑轴的多式疗法,以改善患者护理.
科学领域:
- 胃肠病学 胃肠病学
- 内部医学 内部医学
- 微生物学 微生物学
背景情况:
- 炎症性肠病 (IBD) 患者经常报告炎症后持续的症状.
- 刺激性肠综合征 (IBS) 类似的症状在IBD患者中比一般人群发生的频率高五倍.
- 这些症状显著降低了生活质量,并增加了IBD的医疗保健使用.
研究的目的:
- 审查关于IBD中IBS类症状的当前知识.
- 探索IBD和IBS之间共享的病理生理机制.
- 概述基于证据的诊断和治疗策略.
主要方法:
- 对IBD中IBS样症状现有研究的文献综述.
- 分析共享的病理生理因素,包括遗传学,环境,微生物群和大脑肠道相互作用.
- 综合当前的诊断和治疗方法.
主要成果:
- 存在一个共同的病理生理基础,涉及遗传易感性,环境因素,肠道失生症,增加肠道透性,内脏过敏性和脑肠相互作用.
- 诊断需要排除其他胃肠道疾病,并考虑心理相关疾病.
- 有效的治疗是多模式的,包括药理学,生活方式和基于微生物群的方法.
结论:
- 在IBD中,IBS类症状是一个重要的临床问题,需要特别注意.
- 治疗应该针对肠-大脑轴和患者的福祉,而不仅仅是炎症.
- 调整治疗目标以涵盖全面的患者护理对于这个患者群体至关重要.
相关概念视频
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