在VLDL和LDL颗粒的组成和数量的变化随着甘油三或ApoB度的增加
Justine Cole1, Patrick Couture2, André J Tremblay2
1Mike and Valeria Rosenbloom Centre for Cardiovascular Prevention, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada (Drs Cole and Sniderman).
Journal of clinical lipidology
|November 12, 2024
概括
富含三糖蛋白的脂蛋白 (TRLs) 仅在极端高三糖血症的情况下,对总阿波利波蛋白B (apoB) 产生显著的贡献. 非常低密度脂蛋白胆固醇 (VLDL-C) 不是VLDL-apoB水平的可靠指标.
科学领域:
- 心血管研究研究心血管研究
- 脂质代谢 脂质代谢是什么
- 动脉样硬化病原体的产生
背景情况:
- 富含三糖蛋白脂蛋白 (TRLs) 的动脉激素潜力取决于它们相对于低密度脂蛋白 (LDL) 和总阿波利波蛋白B (apoB) 的颗粒丰度.
- 了解TRL对整体apoB水平的贡献对于评估心血管风险至关重要.
研究的目的:
- 量化TRL对总apoB的贡献,因为甘油三和apoB度上升.
- 分析TRL的组成变化,增加TG或apoB,以评估VLDL胆固醇 (VLDL-C) 是否准确地反映VLDL-apoB.
主要方法:
- 1940年失脂症患者的血样本的顺序超离心.
- 测量血和脂蛋白子分数中的apoB,胆固醇和TG.
- 根据TG或apoB度的四分位数分层的数据分析.
主要成果:
- 在TG和apoB四分位数中观察到所有测量参数的显著变化.
- 随着TG的上升,VLDL-apoB主导了总apoB的增加,但即使在最高的TG四分位数中,LDL-apoB仍然很大 (80%).
- LDL-apoB占整个apoB四分位数中总apoB增加的90%.
- 导致VLDL-C增加的原因是VLDL-C/apoB比率在中度TG水平较高,VLDL-apoB在非常高TG水平较高.
结论:
- 只有在极端高甘油三血的条件下,VLDL-apoB才能成为总apoB的主要贡献者.
- VLDL-C不是VLDL-apoB的合适替代标记物,特别是在失脂症患者中.
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