Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

358
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
358

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A Network Pharmacology Study on the Active Ingredients and Potential Targets of <i>Tripterygium wilfordii</i> Hook for Treatment of Rheumatoid Arthritis.

Evidence-based complementary and alternative medicine : eCAM·2019
Same author

Size-Dependent Relaxation Processes of Photoexcited [ n]Cycloparaphenylenes ( n = 5-12): Significant Contribution of Internal Conversion in Smaller Rings.

The journal of physical chemistry. A·2019
Same author

NfiR, a New Regulatory Noncoding RNA (ncRNA), Is Required in Concert with the NfiS ncRNA for Optimal Expression of Nitrogenase Genes in Pseudomonas stutzeri A1501.

Applied and environmental microbiology·2019
Same author

A novel homolateral and dicationic AIEgen for the sensitive detection of casein.

The Analyst·2019
Same author

Terahertz Oscilloscope for Recording Time Information of Ultrashort Electron Beams.

Physical review letters·2019
Same author

Flexible Transparent Organic Artificial Synapse Based on the Tungsten/Egg Albumen/Indium Tin Oxide/Polyethylene Terephthalate Memristor.

ACS applied materials & interfaces·2019

相关实验视频

Updated: May 8, 2026

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles
09:27

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles

Published on: August 16, 2012

10.7K

核心外向上转换的纳米粒子具有适当的表面修饰,以克服内皮屏障.

Chao Lu1, Jianying Ouyang2, Jin Zhang3,4

  • 1Department of Chemical and Biochemical Engineering, University of Western Ontario, London, ON, N6A 5B9, Canada.

Discover nano
|November 12, 2024
PubMed
概括

用N,N-三甲基 (TMC) 修改的上转化纳米粒子 (UCNPs) 有效克服内皮障碍,改善生物成像传递. 这种电离子修饰增强了跨生物组织的纳米粒子运输.

更多相关视频

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
10:38

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery

Published on: January 15, 2018

12.5K
Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

8.9K

相关实验视频

Last Updated: May 8, 2026

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles
09:27

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles

Published on: August 16, 2012

10.7K
Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
10:38

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery

Published on: January 15, 2018

12.5K
Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

8.9K

科学领域:

  • 材料科学 材料科学 材料科学
  • 生物医学工程 生物医学工程
  • 纳米技术纳米技术

背景情况:

  • 向上转换纳米粒子 (UCNPs) 为生物成像提供了有希望的近红外 (NIR) 到可见光转换.
  • 组织壁垒阻碍了在体内应用中有效的纳米粒子传递.
  • 纳米颗粒的表面修饰对于克服生物障碍至关重要.

研究的目的:

  • 开发用N,N-三甲基 (TMC) 修改的核心外UCNP,以增强内皮屏障的透.
  • 评估TMC修改UCNP的运输效率和生物相容性.
  • 评估这些修改后的UCNP在改善生物成像交付方面的潜力.

主要方法:

  • 核心UCNP (NaGdF4:Yb3+,Tm3+@SiO2) 的合成和表面修饰用聚乙烯甘醇 (PEG) 和TMC.
  • 使用XRD,TEM和泽塔电位测量的表征.
  • 在体外评估内皮质屏障完整性 (TEER,紧密结合蛋白) 和通过模型内皮质屏障的纳米粒子传输.

主要成果:

  • TMC修改显著增加了UCNPs@SiO2-PEG的泽塔潜力,表明了增强的阴离子特性.
  • 经TMC修改的UCNP对HUVEC没有显著的毒性,高达250μg/mL.
  • 在体外内皮膜屏障模型中,TMC修饰的UCNP的运输百分比高达4.56%,明显高于未修饰的UCNP.

结论:

  • 用TMC表面修改的核心UCNP可以有效地克服内皮壁垒.
  • 增强的运输能力表明,在生物成像应用中,有针对性交付的潜力有所提高.
  • TMC 修改是一种可行的策略,可以提高纳米颗粒通过生物障碍的透率.