与BMI相关的序列变异通过BMI本身影响疾病风险
Gudmundur Einarsson1, Gudmar Thorleifsson1, Valgerdur Steinthorsdottir1
1deCODE genetics/Amgen, Inc., Reykjavik, 102, Iceland.
Nature communications
|November 12, 2024
概括
门德尔的随机化研究表明,身体质量指数 (BMI) 的遗传风险影响疾病. 这项研究表明,与BMI变异相关的大部分疾病风险都是通过BMI本身来调解的,而不是其他途径.
科学领域:
- 遗传学 是一个遗传学.
- 流行病学 流行病学
- 代谢疾病 代谢疾病
背景情况:
- 门德尔随机化 (MR) 研究将身体质量指数 (BMI) 与许多疾病联系起来.
- 这些协会的确切调解途径仍然不完全理解.
研究的目的:
- 调查基因倾向于更高的BMI是否仅通过BMI或通过其他生物机制增加疾病风险.
- 为了区分疾病的直接遗传影响与BMI介导的遗传影响.
主要方法:
- 在大人口数据集 (冰岛和英国生物库) 中使用了与BMI遗传风险评分的MR.
- 检查了BMI遗传风险得分与各种疾病结局之间的关联,无论是未调整的还是根据测量BMI的条件.
- 在考虑BMI的影响后,评估了疾病风险关联的减弱.
主要成果:
- 在BMI的条件下,BMI遗传风险得分与包括脂肪肝疾病,葡萄糖不耐受性和膝关节置换在内的疾病之间的关联完全减弱.
- 对2型糖尿病,心力衰竭,心肌梗塞,心房动和关节置换也观察到显著的减弱.
- 慢性病和中风的部分衰减被注意到,有一些变化.
结论:
- 这些发现强烈表明,大多数与BMI相关的遗传变异相关的疾病风险都是通过BMI本身进行的.
- 这突显了BMI降低作为治疗策略的潜力,用于广泛的与肥胖有关的疾病.
- 其余效应需要进一步调查潜在的型变化,BMI的时间变化或其他混因素.
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