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Updated: Jun 7, 2025

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
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染色体间的接触沿着空间梯度划分了基因组拓

Milad Mokhtaridoost1, Jordan J Chalmers1,2, Marzieh Soleimanpoor1

  • 1Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON, M5G 0A4, Canada.

Nature communications
|November 12, 2024
PubMed
概括

非同源染色体接触 (NHCC) 对于基因调节至关重要,但人们对其了解甚少. 一种名为"签名"的新算法识别了数千个NHCC,揭示了它们在人类细胞类型的基因组拓和基因活性中的作用.

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