在未接受过治疗的精神分裂症患者和接受过药物的精神分裂症患者中,长非编码RNA的表达模式
Kamran Javidi Aghdam1, Behzad Baradaran2, Shima Rahmani2
1Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
这项研究揭示了精神分裂症患者的基因表达改变,确定了周围血液中特定的长非编码RNA (lncRNA) 和蛋白质编码基因,这些基因可能作为早期检测的生物标志物.
科学领域:
- 神经科学和遗传学 在神经科学和遗传学.
- 免疫学和分子生物学
背景情况:
- 精神分裂症是一种复杂的精神疾病,影响1%的人口,具有复杂的遗传基础.
- 新出现的证据表明,精神分裂症的发病原因是免疫系统失调和炎症.
- 长非编码RNAs (lncRNAs) 越来越多地被认为是它们在各种生物过程和疾病中的作用.
研究的目的:
- 为了研究精选的lncRNAs和精神分裂症中蛋白质编码基因的外周血液表达模式.
- 为了比较未经治疗的患者,接受药物治疗的患者和健康对照者之间的基因表达特征.
- 评估已识别的基因作为精神分裂症诊断生物标志物的潜力.
主要方法:
- 对四种lncRNA和三种蛋白质编码基因的外周血液基因表达的定量分析.
- 三组基因表达水平的比较:以前没有接受过治疗的精神分裂症患者,接受过药物治疗的精神分裂症患者和年龄/性别匹配的健康对照组.
- 统计分析包括斯皮尔曼相关性和诊断灵敏度和特异性的评估.
主要成果:
- 在接受药物治疗的患者中,IFNG,IL18RAP和AC007278.2被上调,而IFNG-AS1-001与对照组相比被下调.
- 在以前没有接受过治疗的患者中,IFNG,IL18R1,IL18RAP,IFNG-AS1-001,AC007278.2和AC007278.3的调高,IFNG-AS1-003的调低.
- 特定的基因 (IFNG-AS1-003,IFNG,IL18R1,AC007278.3) 显示出高灵敏度和特异性,用于识别以前没有接受过治疗的患者.
结论:
- 该研究强调了精神分裂症患者lncRNA和蛋白质编码基因表达的显著变化.
- 特定的 lncRNAs 显示为潜在的外围生物标志物,可用于早期发现精神分裂症,特别是在未经治疗的个体中.
- 需要进一步的研究来验证这些发现,并确定lncRNAs是精神分裂症的可靠诊断标记.
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