与疾病相关的B细胞和免疫内型为人类SLE的SARS-CoV-2mRNA疫苗接种形成了适应性免疫反应
Caterina E Faliti1,2, Trinh T P Van1,2, Fabliha A Anam1,2
1Department of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
系统性红斑狼 (SLE) 患者由于抗体和免疫细胞的改变而表现出COVID-19疫苗反应减弱. 贝利马布治疗进一步影响疫苗的有效性,因为它影响B细胞和T细胞的原始化.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 类风湿病学 类风湿病学
背景情况:
- 针对COVID-19 (冠状病毒疾病2019) 的mRNA疫苗在一些免疫受损的个体中降低了有效性.
- 导致疫苗反应受损的细胞机制和特定疾病的异常尚不清楚.
研究的目的:
- 研究系统性红斑狼 (SLE) 患者对mRNA COVID-19疫苗接种的血清和细胞免疫反应.
- 探索贝利穆马布治疗对SLE患者疫苗免疫性的影响.
主要方法:
- 疫苗接种后SLE患者的综合血清和细胞分析.
- 评估抗体激烈性,中和效能,B细胞种群 (包括双阴性B细胞) 和T细胞免疫力.
- 开发和应用一个额外毛囊B和T细胞得分.
- 对贝利马布对原始B细胞和T毛囊辅助细胞的影响的评估.
主要成果:
- 在SLE患者中,针对SARS-CoV-2 (严重急性呼吸综合征冠状病毒2) 的抗体激烈度和范围降低.
- 在双阴性 (DN) B细胞群体中观察到持续的抗尖峰反应,在SLE患者中更为普遍.
- 观察到抗尖峰T细胞免疫力受损,以及疫苗效率低与新型外B细胞和T细胞得分之间的相关性.
- 贝利马布治疗与疫苗免疫性不佳有关,抑制了天真B细胞原始化,并影响T毛囊辅助细胞.
结论:
- 不同的B细胞内型促使SLE的疫苗反应变化.
- 抗体和细胞免疫力受损是SLE患者mRNA疫苗有效性降低的基础.
- 使用贝利马布的抗BAFF封锁对这一队列的疫苗免疫性产生了负面影响.
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