不同的胰岛素抵抗替代品与骨关节炎之间的关联:从NHANES 1999-2018进行的横截面研究
Huirong Cai1,2, Zhiqiang Que3, Junzhe Chen4
1Department of Orthopedics, Longyan First Affiliated Hospital of Fujian Medical University, Longyan , Fujian, 364000, China.
BMC musculoskeletal disorders
|November 13, 2024
概括
胰岛素耐药替代品,如TyG-BMI,TyG-WC和TyG-WtHR指数,与骨关节炎 (OA) 密切相关. TyG-WtHR指数在预测OA风险方面表现出最高的准确性.
科学领域:
- 代谢健康 代谢健康
- 类风湿病学 类风湿病学
- 流行病学 流行病学
背景情况:
- 骨关节炎 (OA) 和胰岛素抵抗 (IR) 之间确立的联系.
- 红外替代指数和高胰岛素血糖-高血糖 (HIEC) 之间的验证相关性.
- 关于IR替代品和OA患病率的研究有限.
研究的目的:
- 调查各种IR替代品与OA之间的关联.
- 评估HOMA-IR,TyG,TyG-BMI,TyG-WC和TyG-WtHR指数对OA的预测准确度.
主要方法:
- 使用了来自国家健康和营养检查调查 (NHANES) 的数据.
- 采用多变量逻辑回归分析来评估IR替代物和OA.
- 根据分析中相关的共变量进行调整.
主要成果:
- 经同变量调整后,TyG-BMI,TyG-WC和TyG-WtHR指数与IR显示出显著的正相关性.
- TyG-BMI,TyG-WC和TyG-WtHR指数的第四四分位数与OA风险分别高出2.63,2.65和2.43倍.
- 这些指数显示了与OA患病率的强有力的关联.
结论:
- 与HOMA-IR和TyG指数相比,TyG-BMI,TyG-WC和TyG-WtHR指数与OA表现出更密切和更稳定的关联.
- 在预测OA方面,TyG-WtHR指数提供了最高的准确性,其次是TyG-WC和TyG-BMI.
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