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Updated: Jun 7, 2025

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在KRASG12D驱动的非小细胞肺癌中,PI3K-AKT-mTOR轴作为治疗依赖性存在

W J McDaid1,2,3, L Wilson2,3, H Adderley1,2,4,3

  • 1Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester, UK.

Molecular cancer
|November 13, 2024
PubMed
概括

克拉斯抑制剂对非小细胞肺癌 (NSCLC) 有希望,但耐药性需要组合疗法. 用AKT抑制剂向KRAS G12D可以克服耐药性,与KRAS G12C不同,指导个性化NSCLC治疗.

关键词:
克拉斯 (Kras) 是一个国家.抑制了KRASG12D的发生.在NSCLCLC中,我们可以看到NSCLCLC.在PI3K-AKT-mTOR路径中.

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